DXN Cordyceps

Cordyceps sinensis, the Cordyceps species most widely used as a dietary supplement, naturally grows on the back of the larvae of a caterpillar from the mothHepialus armoricanus Oberthur found mainly in China, Nepal, and Tibet. The mycelium invades the caterpillar and eventually replaces the host tissue. The stroma (fungal fruit body) grows out of the top of the caterpillar. The remaining structures of the caterpillar along with the fungus are dried and sold as the dietary supplement cordyceps.

Commonly known as “dong chong xia cao” (summer-plant, winter-worm) in Chinese, cordyceps has been used as a tonic food in China and Tibet and has been used as a food supplement and tonic beverage among the rich because of its short supply due to over harvesting. It is also an ingredient in soups and other foods used traditionally in Chinese medicine for thousands of years helping debilitated patients recover from illness.

Although written record of Cordyceps sinensis use appeared in Traditional Chinese Medicine centuries ago, it wasn’t really noticed in the West until recently. The last two decades have seen a great increase in research on cordyceps as a medicinal mushroom.

There are many reported cordyceps health benefits. Some of these include:

• Cholesterol reduction
• Stimulation of the immune system
• Faster recovery from bronchitis and respiratory diseases
• Increased efficiency and stamina of the circulatory system
• Anti-tumor properties
• Liver protection and enhanced recovery from chemotherapy
• Sexual issues
• A general body adaptogen, resulting in more energy, strength, and staminaThe reasons behind some of these benefits are still not fully understood. Yet research has found some promising proof behind cordyceps claims. A few of the helpful constituents found are:

Sterols – Alcohols of the steroid group. Believed to lower cholesterol, reduce the risk of heart disease, and possibly have some anti-tumor properties.

Polysaccharides – Complex carbohydrates made up of chains of sugars. Known to stabilize blood pressure, have an effect on free radicals, and stimulate the immune system.

Nucleosides – Organic molecules that are the converted into building blocks of the genetic material DNA and RNA. Nucleoside drugs are sometimes used to treat cancer.

One of the most useful things thatCordyceps sinensis appears to do is the simple act of oxygenation. The fungus dilates the airways in the lungs, resulting in more oxygen to the blood. Thus more oxygen reaches every cell of the body, resulting in better cell function and greater energy levels.

Cordyceps is used therapeutically for asthma, bronchitis, chemoprotection, exercise performance, hepatitis B, hepatic cirrhosis, hyperlipidemia (high cholesterol), as an immunosuppressive agent, and in chronic renal failure.

The fungus became popular in 1993 when two female Chinese athletes, who admitted using cordyceps supplements, beat the world records in the track and field competition at the Stuttgart World Championships for the 1,500-, 3,000-, and 10,000-meter runs. The women were drug tested for any banned substances such as steroids and were negative. Their coach attributed the performance to the cordyceps supplementation.

POTENTIAL HEALTH BENEFITS OF CORDYCEPS

Hepatitis B:

Cordyceps may stimulate the immune system and improve serum gamma globulin levels in hepatitis B patients. Currently, there is insufficient evidence to recommend for or against the use of cordyceps for chronic hepatitis B. However, the results are promising. Additional study of cordyceps and current hepatitis treatments is needed.

Hyperlipidemia (high cholesterol):

Cordyceps may lower total cholesterol and triglyceride levels, although these changes may not be permanent or long lasting. Longer studies with follow up are needed to determine the long-term effects of cordyceps on hyperlipidemia.

Anti-aging:

Cordyceps may improve various symptoms related to aging. However, higher quality studies testing specific symptoms of aging are needed before the effects of cordyceps can be described. Currently, there is insufficient evidence to recommend for or against the use of cordyceps for anti-aging.

Asthma:

Cordyceps may reduce some asthma symptoms. Additional studies are needed to make a firm recommendation.

Bronchitis:

There is insufficient evidence from controlled clinical trials to recommend for or against the use of cordyceps for bronchitis. Most studies using cordyceps have found improved symptoms with cordyceps more than the control drugs. Although results are promising, more studies should be performed before a firm recommendation can be made.

Chemoprotective:

There is insufficient evidence to recommend for or against the use of cordyceps as a chemoprotective agent in aminoglycoside toxicity. However, the results are promising.

Exercise performance enhancement:

In 1993, two female Chinese athletes, who admitted using cordyceps supplements, beat the world records in the track and field competition at the Stuttgart World Championships for the 1,500-, 3,000-, and 10,000-meter runs. However, there is insufficient evidence from conflicting controlled clinical trials to recommend for or against the use of cordyceps for improving exercise performance. More studies are needed in this area.

Immunosuppression:

Two studies using combination herbal treatments that included cordyceps indicate that these combinations suppressed the immune system in kidney transplant and lupus nephritis patients. However, as these treatments used combination products, the effect of cordyceps cannot be defined. More studies with cordyceps as a monotherapy are needed.

Liver disease (hepatic cirrhosis):

In traditional Chinese medicine, cordyceps has been used to support and improve liver function. In two studies using herbal combinations that included cordyceps, liver function improved liver and immune function. However, as these studies used combination treatments, the effect of cordyceps alone is unknown.

Renal failure (chronic):

In traditional Chinese medicine, cordyceps is used to strengthen kidney function. Two studies indicate that cordyceps may improve renal function in patients with chronic renal failure. More studies are needed to confirm these findings.

Diabetes.
Cordyceps may benefit people at risk of diabetes. Researchers from University of Macau, China, isolated a
polysaccharide of molecular weight approximately 210kDa was isolated from cultured Cordyceps mycelia. This isolated polysaccharides, CSP-1, has a strong antioxidant activity and a hypoglycemic effect on normal and alloxan-diabetic mice and streptozotocin (STZ)-diabetic rats. When administered at a dose of higher than 200mg/kg body wt. daily for 7 days, CSP-1 produced a significant drop in blood glucose level in both STZ-induced diabetic rats and alloxan-induced diabetic mice.

Researchers from China Agricultural University, Beijing, also noticed the blood glucose lowering effects of a polysaccharide extracted from the fruting bodies and mycelia of Cordyceps militaris in a study of rats. The hypoglycemic effect of this polysaccharide-enriched Cordyceps militaris extract was dose-dependent. Korean researchers showed a water-extract of Cordyceps militaris ameliorated insulin resistance by enhancing glucose utilization in skeletal muscles of rats.

Anti-oxidative Activities
Cordyceps has antioxidant activities. Researchers from Chia Nan University of Pharmacy and Science,
Taiwan, demonstrated the protective effects of cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage of biomolecules in a vitro study. They both have free radical scavenging abilities.

Cancer
Cordyceps may offer benefits to those suffered from certain cancers. The aqueous extract of Cordyceps sinensis (Cs), one of the traditional Chinese medicines, has been demonstrated to benefit a wide range of disorders in either animal or test-tube studies. Here are some most recent animal or in vitro studies suggesting its benefits in cancers.

Korean researchers reported cytotoxic effects of cultivated fruiting bodies of Cordyceps militaris extracts against the proliferation of the human premyelocytic leukemia cell HL-60 via the activation of caspase-3.

Researchers from Nanjing University shouls that a polysaccharide extracted from a cultivated Cordyceps sinensis fungus significantly enhanced superoxide dismutase activity of liver, brain and serum as well as glutathione peroxidase activity of liver and brain in tumor-bearing mice. It also inhibited H22 tumor growth in the mice.

Hong Kong researchers demonstrated that an ethanol extract of cultivated mycelium of a Cordyceps sinensis fungal mycelium has strong anti-tumor activity on four cancer cell lines MCF-7 breast cancer, B16 mouse melanoma, HL-60 human premyelocytic leukemia and HepG2 human hepatocellular carcinoma. In an animal test, the EtOAc extract showed significant inhibiting effect on B16-induced melanoma in C57BL/6 mice, causing about 60% decrease of tumor size over 27 days. In contrast, this extract had much lower cytotoxicity against normal mouse bone marrow cells.

Cordyceps sinensis is believed to be an immunomodulator.Hong Kong researchers demonstrated that a cultivated strain of Cordyceps sinensis induced the production of interleukin(IL)-1beta, IL-6, IL-10 and tumor necrosis factor alphaalpha from PBMC, augmented surface expression of CD25 on lymphocytes in a vitro study. While, researchers from Zhejiang University, China, desmonstrated increased ovalbumin-specific IgG, IgG1 and IgG2b serum levels after treating the mice with edible mycelia of Cordyceps sinensis.

A rat study has shown that a Cordyceps sinensis mycelium extract protected mice from group A streptococcal infection. It increased IL-12 and IFN-gamma expression and macrophage phagocytic activities.

Memory
Cordyceps may benefit people suffered from memory deficits. The extract of Cordyceps ophioglossoides protected the Abeta-induced neuronal cell death and memory loss through free radical scavenging activity.

Cholesterol Profiles

Cordyceps may benefit people with cholesterol-lowering effects. In a study, researchers fed mice with cholesterol-
enriched diet. They found that the serum total cholesterol (TC) of all mice groups administered Cordyceps sinensis
extracts with the cholesterol-enriched diet decreased more than in the control group.

Heart and Circulation Issues
Cordyceps may offer benefits of cardiovascular protection. Extracts of the fruiting bodies of cultured Cordyceps sinensis has been shown to exert beneficial effects on the formation of the atherosclerotic lesion induced by oxidative stress with few side effects in a study of mice. In the study, researchers fed mice with an atherogenic diet and treated with the extracts for 12 weeks. Mice fed the atherogenic diet showed marked increases in serum lipid and lipid peroxide levels and also aortic cholesterol levels, particularly cholesteryl ester level, a major lipid constituent in atherosclerotic lesions. According to the authors, the extracts significantly suppressed the increased serum lipid peroxide level but not other lipid levels in a dose-dependent manner. WECS also suppressed the increased aortic cholesteryl ester level in a dose-dependent manner.

Researchers isolated a macromolecule from Cordyceps sinensis and they found this molecule has blood pressure lowering and vaso-relaxing effects. The researchers explained that the vasorelaxation was mediated by the endothelium possibly by stimulating the release of the nitric oxide and endothelium-derived hyperpolarizing factor.

OTHER
Cordyceps may also have beneficial effects on kidneys, but, more studies are needed to understand the mechanism. CLINICAL STUDIES ARE NEEDED TO SUPPORT THESE CORDYCEPS BENEFITS.

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious and should be evaluated by a qualified healthcare provider.